| 10/1/21 | Boys Soccer | Varsity Boys Soccer Tournament: Camdenton Tournament | Camdenton | |
| 10/1/21 | Softball | Varsity Softball Tournament: Springfield Invitational | Springfield | |
| 10/1/21 | Swimming | Boys Swimming and Diving Away Meet at Camdenton (V) | Springfield | 4:30 PM |
| 10/1/21 | Football | 11-Man Football vs. Joplin (V) | Republic | 7:00 PM |
| 10/2/21 | Volleyball | Freshman Girls Volleyball Tournament: Cassville 9th Grade/C Team Tourney | Cassville | |
| 10/2/21 | Cross Country | Varsity Boys Cross Country Tournament: Laker Invitational at Collins Farm | Camdenton | |
| 10/2/21 | Volleyball | Varsity Girls Volleyball Tournament: Mt. Vernon Varsity Tournament | Mount Vernon | |
| 10/4/21 | Golf | Varsity Girls Golf Tournament: COC Tournament | Joplin | |
| 10/4/21 | Volleyball | Girls Volleyball vs. Parkview (V, JV, Fr) | Republic | 4:30 PM |
| 10/4/21 | Football | 11-Man Football at Joplin (JV) | Joplin | 6:00 PM |
| 10/4/21 | Football | 11-Man Football vs. Joplin (Fr) | Republic | 6:00 PM |
| 10/5/21 | Softball | Softball at Ozark (V, JV) | Ozark | 4:30 PM |
| 10/5/21 | Volleyball | Girls Volleyball vs. Willard (V, JV, Fr) | Republic | 4:30 PM |
| 10/5/21 | Boys Soccer | Boys Soccer vs. Webb City (V, JV) | Republic | 5:00 PM |
| 10/7/21 | Volleyball | Girls Volleyball vs. Joplin (V, JV, Fr) | Republic | 4:30 PM |
| 10/7/21 | Boys Soccer | Boys Soccer at Rolla (V, JV) | Rolla | 5:00 PM |
| 10/8/21 | Swimming | Boys Swimming and Diving Away Meet at Waynesville (V) | Springfield | 4:30 PM |
| 10/8/21 | Football | 11-Man Football vs. Carl Junction (V) | Republic | 7:00 PM |
| 10/9/21 | Volleyball | Junior Varsity Girls Volleyball Tournament: Volleyfest JV Tournament | Springfield | |
| 10/9/21 | Cross Country | Varsity Boys Cross Country Tournament: Branson Invitational | Branson | |
| 10/11/21 | Football | 11-Man Football at Carl Junction (JV) | Carl Junction | 6:00 PM |
| 10/11/21 | Football | 11-Man Football vs. West Plains (Fr) | West Plains | 6:00 PM |
| 10/12/21 | Swimming | Boys Swimming and Diving Away Meet at Central (Springfield) (V) | Springfield | 4:30 PM |
| 10/12/21 | Volleyball | Girls Volleyball vs. Nixa (V, JV, Fr) | Republic | 4:30 PM |
| 10/12/21 | Boys Soccer | Boys Soccer at Branson (V, JV) | Branson | 5:00 PM |
| 10/14/21 | Volleyball | Girls Volleyball at Webb City (V, JV, Fr) | Webb City | 4:30 PM |
| 10/14/21 | Boys Soccer | Boys Soccer vs. Bolivar (V, JV) | Republic | 5:00 PM |
| 10/15/21 | Football | 11-Man Football at Carthage (V) | Carthage | 7:00 PM |
| 10/18/21 | Football | 11-Man Football at Carthage (Fr) | Carthage | 6:00 PM |
| 10/18/21 | Football | 11-Man Football vs. Carthage (JV) | Republic | 6:00 PM |
| 10/19/21 | Cross Country | Varsity Boys Cross Country Tournament: COC Meet | Nixa | |
| 10/19/21 | Swimming | Varsity Boys Swimming and Diving Tournament: COC Meet | Webb City | |
| 10/19/21 | Volleyball | Girls Volleyball at Ozark (V, JV, Fr) | Ozark | 4:30 PM |
| 10/19/21 | Boys Soccer | Boys Soccer at Carl Junction (V, JV) | Carl Junction | 5:00 PM |
| 10/22/21 | Boys Soccer | Junior Varsity Boys Soccer Tournament: Kickapoo JV Tournament | Springfield | |
| 10/22/21 | Swimming | Boys Swimming and Diving Away Meet at Rockhurst (V) | Springfield | 4:30 PM |
| 10/22/21 | Football | 11-Man Football vs. Branson (V) | Republic | 7:00 PM |
| 10/23/21 | Swimming | Varsity Boys Swimming and Diving Tournament: Springfield Invite | Springfield | |
| 10/25/21 | Football | 11-Man Football at Branson (JV) | Branson | 6:00 PM |
| 10/25/21 | Football | 11-Man Football vs. Branson (Fr) | Republic | 6:00 PM |
| 10/26/21 | Boys Soccer | Boys Soccer at Nixa (V, JV) | Nixa | 5:00 PM |
| 10/27/21 | Boys Soccer | Boys Soccer vs. Kickapoo (V, JV) | Republic | 5:00 PM |
| 10/29/21 | Swimming | Varsity Boys Swimming and Diving Tournament: SWMO Diving/Swim Prelims | Springfield | |
| 10/30/21 | Swimming | Varsity Boys Swimming and Diving Tournament: SWMO Swim Finals | Springfield | |
